Ranitidine differs from cimetidine in the following respect:
A. It is less potent
B. It is shorter acting
C. It does not have antiandrogenic action
D. It produces more CNS side effects
Answer: C. It does not have antiandrogenic action
Ranitidine and cimetidine are two H2 receptor inhibitors used to treat gastrointestinal illnesses such as ulcers by lowering acid production in the stomach.
The distinction between the two is that cimetidine has antiandrogenic properties by blocking androgen receptors while ranitidine does not.
Cimetidine intake may cause loss of libido, impotence and gynecomastia in males because of its antiandrogen characteristics. Unlike ranitidine, which is specific to H2 histamine receptors and does not bind to the androgen receptor has no sexual side effects.
The other statements are incorrect; in terms of potency and duration, ranitidine is comparable to cimetidine. Ranitidine also does not necessarily cause additional CNS side effects.
In brief, the essential difference between ranitidine and cimetidine is that since it lacks bothersome antiandrogenic actions of cimetidine . This rendered ranitidine a better choice than cimetidine for most patients.
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