Where does ADH have its greatest effect? A. Loop of Henle.

1. Where does ADH have its greatest effect?

A. Loop of Henle.

B. Proximal convoluted tubule.

C. Distal convoluted tubule.

D. Glomerulus.

Answer: C. Distal convoluted tubule.

Acutely, vasopressin or antidiuretic hormone has its maximum activity in the distal convoluted tubule or the nephron in the kidneys. The fine-tuning of the composition of the urine is the distal convoluted tubule as it has part of the nephron.

ADH is also interested in the quantity of water reclaimed in the distal convoluted tubule. When the levels of ADH increase this increases the permeability of the tubule cells which in turn assists in reabsorbing more water back to the bloodstream from the filtrate. This results in production of the concentrated urine which is essential in the control of water content and pressure in the body.

ADH interacts with distal convoluted tubules as part of the mechanism to avoid the loss of too much water within the kidneys.